In February 2005, Dodge introduced a new fullsize rear wheel drive Charger on the Chrysler LX platform also used by the Chrysler 300 and Dodge Magnum (the interior of the Charger is almost identical to that of the Magnum). Also, it replaced the Dodge/Chrysler Intrepid. This 2006 model year car is a four-door sedan, disappointing fans of the previous two-door Chargers. It is built in Brampton, Ontario, Canada.

The base engine (for the Charger SE and SXT) is Chrysler's 3.5 L V6 which produces 250 hp (186 kW) and 250 ft·lbf (339 N·m) of torque. This version of the car sells for US$22,995.

The Hemi R/T version uses the 5.7 L Hemi V8 and sells for US$29,995. This engine produces 340 hp (254 kW) and 390 ft·lbf (475 N·m) of torque. 65% of Charger buyers are opting for the Hemi-powered R/T model with an average sale price of $32,722. In 2005, Dodge announced a new Police Package version of the Charger with upgraded brakes and either the 3.5L or Hemi engine.

The 2006 Charger Daytona R/T debuted at the Chicago Auto Show. It features a High Output 350 hp (261 kW) version of the 5.7 L Hemi as well as an updated suspension and tires. Visual additions include a special front fascia with a chin spoiler. In a retro touch, the Daytona R/T features black "Hemi" decals on the hood and rear fender and is only available in two retro colors: "Go ManGo!" metallic orange (from the 1970 Charger) and Top Banana yellow (also a 1970-vintage color). It is priced at $32,495 and 8,000 will be produced for one year only. "TorRed" was announced as a new color in January 2006.

An SRT-8 version of the Charger debuted at the 2005 New York International Auto Show. Powered by a 425 hp (317 kW) version of the 6.1 L Hemi, it also features upgraded Brembo brakes, and interior and exterior updates. The engine produces 420 ft·lbf (569 N·m) of torque. This power rating makes the 2006 SRT-8 as powerful as the largest of the legendary Hemi engines of the muscle car era.

A new Super Bee version of the Charger debuted at the 2006 New York International Auto Show for the 2007 model year. It shares the SRT-8's 425 hp (317 kW) 6.1 L Hemi engine but comes in special "detonator yellow" paint with black decals.