The Quest was redesigned in 2004 whereas the Villager was discontinued in 2002. Production moved to Canton, Mississippi. The current "aggressive" design bears a passing resemblance to major shareholder Renault's Scénic. The Quest is powered by their well-known V6 3.5-litre VQ35 model engine, found in the Maxima, Altima 350Z and Infiniti's G35. In the Quest's application it produces 240 horsepower and 242 ft-lb of torque. The Quest has a flat folding rear bench and the two captain's chairs fold nearly flat into the floor. The interior volume is 211.9 cubic feet

The second generation Quest has been both praised and criticized for its avant-garde styling. Some appreciate the attempt to inject the conservative minivan category with a dose of style, but others find the styling (particularly the interior) strange and offputting. The center-mounted instrument panel -- the speedometer and tachometer are in the center of the dash, rather than in front of the driver -- has been especially criticized. Sales of this second generation model have been disappointing, and Nissan is planning to redesign the much-criticized interior for the 2007 model.